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APPLICATIONS

Pd (0) EnCat™ 30NP

Dehalogenation

Dehalogenation
Run Pd loading mol(%) Product (%)
1 0.4 94
2 0.4 95
3 0.4 95
4 0.4 95
5 0.4 95
  • 95% yield
  • Min 4 recycles compared to no recycles with Pd/C
  • Recovery of Pd – 98%

Aromatic Nitro Compounds

Pd(0) EnCat™ 30NP is an effective catalyst for the reduction aromatic nitro compounds and its use has been reported in the reductive cyclisation of Leimgruber-Batcho derived enamine derivatives to form the corresponding indoles.
Leimgruber-Batcho Indole Synthesis
Aromatic Nitro Compounds
Experimental Conditions: a. Microwave heating, DMF, Lewis acid. b. 6 mol% Pd(0) EnCat™ 30NP, EtOAc, HCOOH, NEt3, 24°C, 24 hours or 6 mol% Pd(0) EnCat™ 30NP, EtOAc, HCOOH, NEt3, microwave heating, 120°C, 2 hours

Debenzylation

Pd(0) EnCat™ 30NP can be an efficient catalyst for the selective reductive hydrogenation of aryl benzyl ethers, benzyl esters, and benzyl amines leaving other sensitive groups intact.
Alkyl benzyl ethers are not reduced under atmospheric pressure of hydrogen with Pd(0) EnCat™ 30NP
Reaction Conversion (%)
Aromatic Nitro Compounds 100
Aromatic Nitro Compounds 100
Aromatic Nitro Compounds 100
Experimental Procedure:
The substrate was dissolved in EtOH, 10 mol% of the catalyst (water wet) was added and the mixture degassed twice under vacuum refilling each time with hydrogen. The reaction mixture was left at room temperature overnight connected to hydrogen. The catalyst was then filtered off and washed with EtOH. The filtrate was concentrated to give a crude product which was submitted for 1H-NMR analysis to determine the conversion

Double Bond Reaction

Ketone and Aldehyde reduction and Reductive Amination:
Pd(0) EnCat™ 30NP is an efficient catalyst for the reductive hydrogenation of alkenes, aryl chlorides and aryl alkynes
Reaction Conversion (%)
Double Bond Reaction 100
Double Bond Reaction 100
Double Bond Reaction 100
Double Bond Reaction 88
Double Bond Reaction 100